Consortium member

Ivy Aneas-Swanson


Research Associate

Main Research Interests

  • Gene regulation
  • Epigenetics
  • Regulatory variants


Ivy is currently a Research Associate Professor in the Department of Human Genetics at the University of Chicago.

Ivy has a degree in biology from São Paulo State University in Brazil. She received her Masters and PhD in Molecular Biology from São Paulo Federal University studying the genetics of hypertension. Moving to USA in 2005, she pursued postdoctoral training with Marcelo Nobrega at the University of Chicago dissecting the regulatory network of TBX20, a gene linked with both congenital cardiac malformations as well as late adult-onset cardiac diseases. Her studies investigating the dual role of this transcription factor showed how the combination of genomics and classical physiology readily uncovered the molecular basis for complex phenotypes that would be otherwise difficult to establish.

In 2011 she became a research assistant and has been working on several projects to characterize the impact of noncoding variants in gene expression and human diseases (obesity, prematurity and asthma).  From 2017-2019 she served as the Research Scientific Manager for the University of Chicago, Northwestern University Feinberg School of Medicine and Duke Medicine Prematurity Research Center.

Key Research Outputs

Asthma-associated variants induce IL33 differential expression through an enhancer-blocking regulatory region. Aneas, I.*, Decker, D.C.*, et al. (2021) Nature Communications 12(1):6115 *equal contribution.

Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5. Sobreira, D.R., […] Aneas, I., Nóbrega, M.A. (2021) Science 372(6546):1085-1091.

Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth. Sakabe, N.J.*, Aneas, I.*, et al. (2020) Science Advances 6(49):eabc8696 *equal contribution.

Probing chromatin landscape reveals roles of endocardial TBX20 in septation. Boogerd, C.J.*, Aneas, I.*, et al. (2016) The Journal of Clinical Investigation 126(8):3023-35 *equal contribution.

Dual transcriptional activator and repressor roles of TBX20 regulate adult cardiac structure and function. Sakabe, N.J.*, Aneas, I.*, et al. (2012) Human Molecular Genetics 21(10):2194-204 *equal contribution.

Tbx20 regulates a genetic program essential to cardiomyocyte function. Shen, T.*, Anes, I.*, et al. (2011) The Journal of Clinical Investigation 121(12):4640-54 *equal contribution.