Consortium member
Robert Mitchell
Biography
Rob was born in Elgin, Illinois (USA) and attended Northern Illinois University where he studied biochemistry and biology. He received his PhD in Molecular and Cellular Biochemistry from Loyola University Chicago and was a postdoctoral fellow at the NIH in Bethesda, Maryland. While at the NIH he studied ErbB4 receptor signalling in GABAergic interneurons with Andres Buonanno and then interneuron electrophysiology with Chris McBain. Rob had a brief tenure as a Research Scientist studying NMDA receptor pharmacology at Aptinyx Inc. before joining the lab of Marcelo Nobrega at the University of Chicago as a staff scientist.
Key Research Outputs
Ethanol preconditioning of rat cerebellar cultures targets NMDA receptors to the synapse and enhances peroxiredoxin 2 expression. Mitchell, R.M., et al. (2016). Brain Research 1642:163-169.
A negative feedback loop controls NMDA receptor function in cortical interneurons via Neuregulin 2/ErbB4 signaling. Vullhorst, D.*, Mitchell, R.M.*, et al. (2015) Nature Communications 6:7222 *Equal contribution.
ErbB4 reduces synaptic GABAA currents independent of its receptor tyrosine kinase activity. Mitchell, R.M., et al. (2013) PNAS 110, 19603-19608.
Essential involvement of the NMDA receptor in ethanol preconditioning-dependent neuroprotection from amyloid β in vitro. Mitchell, R.M., Neafsey, E.J., and Collins M.A. (2009) Journal of Neurochemistry 111: 580-588.